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Direct repair (nerve grafting), neurotization, and end-to-side neurorrhaphy in the treatment of brachial plexus injury.

by Haninec P, Sámal F, Tomás R, Houstava L, Dubovwý P
Journal of neurosurgery.

Article Abstract:

OBJECT: The authors present the long-term results of nerve grafting and neurotization procedures in their group of patients with brachial plexus injuries and compare the results of "classic" methods of nerve repair with those of end-to-side neurorrhaphy. METHODS: Between 1994 and 2006, direct repair (nerve grafting), neurotization, and end-to-side neurorrhaphy were performed in 168 patients, 95 of whom were followed up for at least 2 years after surgery. Successful results were achieved in 79% of cases after direct repair and in 56% of cases after end-to-end neurotization. The results of neurotization depended on the type of the donor nerve used. In patients who underwent neurotization of the axillary and the musculocutaneous nerves, the use of intraplexal nerves (motor branches of the brachial plexus) as donors of motor fibers was associated with a significantly higher success rate than the use of extraplexal nerves (81% compared with 49%, respectively, p = 0.003). Because of poor functional results of axillary nerve neurotization using extraplexal nerves (success rate 47.4%), the authors used end-to-side neurorrhaphy in 14 cases of incomplete avulsion. The success rate for end-to-side neurorrhaphy using the axillary nerve as a recipient was 64.3%, similar to that for neurotization using intraplexal nerves (68.4%) and better than that achieved using extraplexal nerves (47.4%, p = 0.19). CONCLUSIONS: End-to-side neurorrhaphy offers an advantage over classic neurotization in not requiring sacrifice of any of the surrounding nerves or the fascicles of the ulnar nerve. Typical synkinesis of muscle contraction innervated by the recipient nerve with contraction of muscles innervated by the donor was observed in patients after end-to-side neurorrhaphy.

Functional Outcome

By: Lawrence Green - Tue 3/27/2007 AM
Some detailed information about functional outcome would be most helpful. Details about motor skills recovered, sensory abilities and disabilities-pain, dysesthesias, etc, return to work, etc.

Direct repair (nerve grafting), neurotization, and end-to-side neurorrhaphy in the treatment of brachial plexus injury.

By: Anonymous - Tue 3/27/2007 AM
In this series of 168 brachial plexus injury patients, 95 (57%) had adequate 2-year follow-up and were evaluated as to the effect different repair techniques had on outcome. The techniques compared included nerve grafting, intraplexal nerve transfers, extraplexal nerve transfers, and end-to-side neurorrhaphy. The best results were seen after graft repair, with 79% of grafted elements having an M3 or better outcome. Intraplexal nerve transfers faired better than extraplexal transfers for both the axillary (68% vs. 47%) and musculocutaneous nerve (94% vs. 50%). Examining Table 5, the majority of extraplexal transfers for the axillary nerve were from the intercostals (16/20), and for the musculocutaneous nerve from the spinal accessory (26/30). It is uncertain if interposition grafts were required for these transfers. These extraplexal transfers were compared to intraplexal transfers to the axillary and musculocutaneous nerves. Intraplexal transfers were from a combination of the medial pectoral, thoracodorsal, and long thoracic nerves (35/35).

Because of incomplete follow-up in 43% of patients, as well as the likelihood that patients undergoing extraplexal transfers were more likely to have a more severe injuries to begin with (e.g., one would tend not to harvest intercostals for transfer to the axillary nerve if multiple intraplexal donors are available), their conclusion that intraplexal transfers per se have a better chance of success than extraplexal donors is uncertain. Also, one may argue that their extraplexal donor group does not represent the more common extraplexal donors used by other authors (intercostals to musculocutaneous, ulnar/median fascicles to the biceps/brachialis branches, triceps branch to axillary, and spinal accessory to suprascapular).

Presumably as a result of their poorer outcomes after extraplexal nerve transfer, in 14 patients where no intraplexal nerve was available for axillary nerve coaptation, they performed an end-to-side neurorrhapy of the axillary nerve to either the ulnar or median nerves (13/14) via an epineurial window. Fascicles were not cut and transferred during these procedures. Their axillary nerve results were comparable to the intraplexal transfers: 64% had good function after end-to-side repair. The authors concluded that end-to-side neurorrhaphy may be better than extraplexal transfer.

Regarding the axillary nerve outcomes in Figure 3, a successful result was defined as M3 or better function with at least 45 degrees of abduction and/or flexion. However, because they did not specifically account for scapular rotation and possible contribution from the supraspinatus to this 45 degrees, one cannot make strong conclusions as to the efficacy of each technique. Nevertheless, it is promising that end-to-side neurorrhaphy of the axillary nerve can potentially yield significant reinnervation.

Source: http://peripheralnervesurgery.blogspot.com/
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